SAINTS welcome Seria A giants Lazio to St Mary's on Wednesday, August 7 as they continue to prepare for the 2024/25 campaign.
The Italian side will present Southampton with their biggest challenge of pre-season so far - although they have faced top-tier opponents Montpellier already.
Southampton have so far recorded wins over Eastleigh, Bordeaux, Montpellier and Millwall and tasted defeat at Championship Oxford United.
Wednesday evening's game against Lazio kicks off at 7.30pm, with a stream accessible via southamptonfc.com and the Saints app. A stream pass costs £5.
READ MORE: 'Last opportunity' - Martin sets out expectations for final pre-season friendlies
The stream will start shortly before Saints get under way in their sixth pre-season encounter.
The Daily Echo will also be at St Mary's to provide minute-by-minute updates, analysis and post-match reaction from Russell Martin and the players.
READ MORE: Key talking points ahead of Southampton vs Lazio pre-season friendly
French forward Sekou Mara is expected to return to the squad having missed Saturday's trip to Millwall through injury.
Martin has explained that two different teams will play this week with Saints also scheduled to welcome La Liga outfit Getafe on Saturday.
Southampton get their Premier League campaign started with an opening weekend trip to Newcastle United on Saturday, August 13.
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