Saints will get the away dressing room at Wembley when they take on Chelsea in the FA Cup semi-final.
Mark Hughes will lead his side out at Wembley on either April 21 or 22 for the showpiece tie after Saints booked their place in the last four with a 2-0 win at Wigan.
The other semi-final will see Manchester United take on Tottenham.
The exact dates for the matches will be confirmed once TV have made their selections for the games, and the clubs and police have been consulted.
Saints face the Blues in the Premier League the weekend before the semi-final tie. Chelsea have won the last four meetings between the sides.
Antonio Conte’s team made it through to the semi-finals with a 2-1 victory over Leicester, which was secured in extra-time.
Alvaro Morata scored for the first time this year when he broke the deadlock shortly before half-time with a composed finish, only for Foxes striker Jamie Vardy to level inside the final quarter of an hour from close range after a goalmouth scramble.
But the tie was settled in extra-time when Chelsea substitute Pedro pipped Leicester goalkeeper Kasper Schmeichel to N'Golo Kante's left-wing cross.
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